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diazepam intranasal and codeine equally maximize sedation. Avoid or Use Alternate Drug. Restrict use to sufferers for whom option therapy options are inadequate
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Conditions of adrenal insufficiency have already been reported here with opioid use, extra normally adhering to higher than 1 thirty day period of use; if adrenal insufficiency is suspected, affirm prognosis with diagnostic screening as quickly as possible; if adrenal insufficiency is diagnosed, deal with with physiologic alternative doses of corticosteroids; wean individual off of opioid read more to allow adrenal perform to recover and keep on corticosteroid therapy until finally adrenal perform recovers
Use is contraindicated in sufferers obtaining monoamine oxidase inhibitors (MAOIs) or more info in just fourteen days of halting such therapy; MAOIs may potentiate effects of codeine’s active metabolite, such as respiratory depression, coma, and confusion